Journal
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Volume -, Issue 99, Pages -Publisher
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/52197
Keywords
Medicine; Issue 99; Heart; mouse model; myocardial infarction; myocardial ischemia; ventricular remodeling; scar formation; LAD ligature
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Funding
- Interdisciplinary Centre for Clinical Research IZKF Aachen within faculty of Medicine at RWTH Aachen University
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Myocardial infarction still remains the main cause of death in western countries, despite considerable progress in the stent development area in the last decades. For clarification of the underlying mechanisms and the development of new therapeutic strategies, the availability of valid animal models are mandatory. Since we need new insights into pathomechanisms of cardiovascular diseases under in vivo conditions to combat myocardial infarction, the validity of the animal model is a crucial aspect. However, protection of animals are highly relevant in this context. Therefore, we establish a minimally invasive and simple model of myocardial infarction in mice, which assures a high reproducibility and survival rate of animals. Thus, this models fulfils the requirements of the 3R principle (Replacement, Refinement and Reduction) for animal experiments and assure the scientific information needed for further developing of therapeutical strategies for cardiovascular diseases.
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