Journal
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
Volume 11, Issue 1, Pages 45-52Publisher
SAGE PUBLICATIONS LTD
DOI: 10.5301/JABFM.2012.9253
Keywords
Chondrocyte; Extracellular matrix; Surface modification; Tissue engineering
Funding
- National Science Council in Taiwan [98-2627-B-006-018-]
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Tissue engineering provides a new strategy for repairing damaged cartilage. Surface and mechanical properties of scaffolds play important roles in inducing cell growth. Aim: The aim of this study was to fabricate and characterize PLGA and gelatin/hyaluronic acid-treated PLGA (PLGA-GH) sponge scaffolds for articular cartilage tissue engineering. Methods: The PLGA-GH scaffolds were cross-linked with gelatin and hyaluronic acid. Primary chondrocytes isolated from porcine articular cartilages were used to assess cell compatibility. The characteristic PLGA-GH scaffold was higher in water uptake ratio and degradation rate within 42 days than the PLGA scaffold. Results: The mean compressive moduli of PLGA and PLGA-GH scaffolds were 1.72 +/- 0.50 MPa and 1.86 +/- 0.90 MPa, respectively. The cell attachment ratio, proliferation, and extracellular matrix secretion on PLGA-GH scaffolds are superior to those of PLGA scaffolds. Conclusions: In our study, PLGA-GH scaffolds exhibited improvements in cell biocompatibility, cell proliferation, extracellular matrix synthesis, and appropriate mechanical and structural properties for potential engineering cartilage applications.
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