Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 277, Issue -, Pages 78-88Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.06.005
Keywords
Serotonin; Tryptophan hydroxylase 2; Animal model; Behavior; Serotonin transporter; Serotonin receptors
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Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT), a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the central nervous system. In 2003 we have discovered the existence of a second Tph gene, which is expressed exclusively in the brain, and, therefore, is responsible for the 5-HT synthesis in the central nervous system. In the following years several research groups have independently generated Tph2-deficient mice. In this review we will summarize the data gained from the existing mouse models with constitutive or conditional deletion of the Tph2 gene, focusing on biochemical, developmental, and behavioral consequences of Tph2-deficiency. (C) 2014 Elsevier B.V. All rights reserved.
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