Journal
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
Volume 28, Issue 4, Pages 542-549Publisher
OXFORD UNIV PRESS
DOI: 10.1093/icvts/ivy280
Keywords
Muscle; Computed tomography; Lung cancer; Pneumonectomy; Risk stratification; Overall survival
Ask authors/readers for more resources
OBJECTIVES: To assess the prognostic role of thoracic muscle as quantified on preoperative computed tomography (CT) for the estimation of overall survival (OS) following pneumonectomy. METHODS: Muscle cross-sectional area (CSA) at the level of the fifth (T5) and eighth (T8) thoracic vertebra was measured on CT scans of consecutive patients with lung cancer prior to pneumonectomy. We stratified patients into high and low muscle groups using the gender-specific median of muscle CSA as separator and estimated associations of muscle CSA and OS using the Kaplan-Meier analysis. Multivariable logistic regression adjusted for body mass index, Charlson comorbidity index (includes age), forced expiratory volume in the first second as a % of predicted, sex, race, smoking status, tumour stage and prior lung cancer treatment was performed. RESULTS: A total of 128 patients were included (61.0 +/- 10.6 years of age, mean body mass index of 26.9 kg/m(2), 55.5% men). The T8 level showed fewer artefacts and strong correlation with the T5 level (Pearson's rho=0.904). T8 CSA was therefore used for subsequent analyses. Mean T8 CSA was 118.5 cm(2) (median 115.3 cm(2)) in men and 75.2 cm(2) (median 74.0 cm(2)) in women. During a median follow-up of 23.6 months (interquartile range 39.3), 65 patients (50.8%) died, of whom 41 were in the low muscle group. The Kaplan-Meier analysis showed significantly longer OS in the high muscle group (log-rank P=0.02). Multivariable analysis showed an independent association of muscle CSA and OS (P=0.02) with a hazard ratio of 0.80 (confidence interval 0.67-0.98) per 10-cm(2) increment. CONCLUSIONS: Thoracic muscle is independently associated with long-term overall survival following pneumonectomy for lung cancer and may contribute to refined survival estimates in this population.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available