Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 291, Issue -, Pages 377-384Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2015.05.051
Keywords
SB-334867; EEG/EMG; Progressive ratio; Addiction; Drug abuse; Orexin
Categories
Funding
- United states National Institute on Drug Abuse [R01DA025279]
Ask authors/readers for more resources
Recent evidence suggests that blockade of the hypocretin receptor 1 may act as a useful pharmacotherapy for cocaine abuse. Here we investigated the extent to which various doses of a hypocretin receptor 1 antagonist, SB-334867, affect cocaine self-administration at varying doses of cocaine and across a range of effort requirements, and tested if these SB-334867 doses produce sedative effects. First, we trained animals to self-administer one of three doses of cocaine on a progressive ratio schedule, and then tested the effects of three doses of SB-334867. Responding for cocaine was then analyzed to segregate features of relatively high and low effort requirements across the progressive ratio session. In another set of experiments, we tested potential sleep-promoting effects of the same doses of SB-334867. Our data indicate that blockade of hypocretin receptor 1 preferentially reduces high effort responding for cocaine at levels that do not promote sedation. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available