Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 8, Issue 10, Pages 3889-3921Publisher
MDPI
DOI: 10.3390/ijerph8103889
Keywords
Guam; cycad; methylazoxymethanol (MAM); beta-N-methylamino-L-alanine (L-BMAA); DNA damage; tauopathy; neurodegenerative disease; amyotrophic lateral sclerosis (ALS); parkinsonism-dementia; nitrosamines; formaldehyde
Funding
- National Institutes of Health (NIH) National Institute of Environmental Health Sciences [ES11384]
- NIH Fogarty Center
- U.S. Army Medical Research Materiel Command [DAMD 17-98-1-8625]
- American Health Assistance Foundation (AHAF)
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Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex, a disappearing neurodegenerative disease linked to use of the neurotoxic cycad plant for food and/or medicine, is intensively studied because the neuropathology (tauopathy) is similar to that of Alzheimer's disease. Cycads contain neurotoxic and genotoxic principles, notably cycasin and methylazoxymethanol, the latter sharing chemical relations with nitrosamines, which are derived from nitrates and nitrites in preserved meats and fertilizers, and also used in the rubber and leather industries. This review includes new data that influence understanding of the neurobiological actions of cycad and related genotoxins and the putative mechanisms by which they might trigger neurodegenerative disease.
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