Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 7, Issue 3, Pages 711-728Publisher
MDPI AG
DOI: 10.3390/ijerph7030711
Keywords
genetic epidemiology; causality; observational studies; instrumental variables
Funding
- Swiss School of Public Health Plus
- Swiss Science Foundation [3200BO-111362/1, 3200BO-111361/1, 33CM30/124087/1]
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Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a. Mendelian randomization. approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.
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