Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 10, Issue 2, Pages 263-279Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/hv.26902
Keywords
Japanese encephalitis virus; vaccine; immunization; biodefense; prevention; pathogenesis; virulence; flavivirus
Categories
Funding
- National Institutes of Health [AI101464]
- Utah Science Technology and Research funds
- Korean National Research Foundation [2007-0052563]
- Utah Agricultural Experiment Station
- Utah State University
- National Research Foundation [532-2008-1-C00011]
- Korean Ministry of Education, Science, and Technology
- National Research Foundation of Korea [532-2008-1-C00011, 2007-0052563] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Japanese encephalitis (JE) is an infectious disease of the central nervous system caused by Japanese encephalitis virus (JEV), a zoonotic mosquito-borne flavivirus. JEV is prevalent in much of Asia and the Western Pacific, with over 4 billion people living at risk of infection. In the absence of antiviral intervention, vaccination is the only strategy to develop long-term sustainable protection against JEV infection. Over the past half-century, a mouse brain-derived inactivated vaccine has been used internationally for active immunization. To date, however, JEV is still a clinically important, emerging, and re-emerging human pathogen of global significance. In recent years, production of the mouse brain-derived vaccine has been discontinued, but 3 new cell culture-derived vaccines are available in various parts of the world. Here we review current aspects of JEV biology, summarize the 4 types of JEV vaccine, and discuss the potential of an infectious JEV cDNA technology for future vaccine development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available