Journal
GENOME MEDICINE
Volume 5, Issue -, Pages -Publisher
BMC
DOI: 10.1186/gm479
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Funding
- National Cancer Institute [5U54 CA119347, R01 CA170689-01]
- National Institutes of Health [NIH 1 U01 CA164252-01, U54 CA143798]
- NATIONAL CANCER INSTITUTE [U54CA151819, R01CA170689] Funding Source: NIH RePORTER
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Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years and are providing approaches for directly elucidating phosphoprotein signaling networks in cancer cells or for capturing high-resolution snapshots of immune system function in patients with various disease conditions. We discuss advances in single-cell proteomics platforms, with an emphasis on microchip methods. These methods can provide a direct correlation of morphological, functional and molecular signatures at the single-cell level. We also provide examples of how those platforms are being applied to both fundamental biology and clinical studies, focusing on immune-system monitoring and phosphoprotein signaling networks in cancer.
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