Journal
GENOME MEDICINE
Volume 2, Issue -, Pages -Publisher
BMC
DOI: 10.1186/gm191
Keywords
-
Categories
Funding
- [R01 CA60499]
- [CA89406]
- NATIONAL CANCER INSTITUTE [R01CA060499, R01CA089406] Funding Source: NIH RePORTER
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Anchored ChromPET, a technique to capture and interrogate targeted sequences in the genome, has been developed to identify chromosomal aberrations and define breakpoints. Using this method, we could define the BCR-ABL1 translocation DNA breakpoint to a base-pair resolution in Philadelphia chromosome-positive samples. This DNA-based method is highly sensitive and can detect the fusion junction using samples from which it is hard to obtain RNA or cells where the RNA expression has been silenced.
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