Journal
GENOME MEDICINE
Volume 1, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/gm85
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Funding
- National Institutes of Health [HL080133]
- American Heart Association [09GRNT2250567]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL095707, R01HL080133] Funding Source: NIH RePORTER
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MicroRNAs (miRNAs) represent a class of small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have identified that miR-145 is the most abundant miRNA in normal arteries and vascular smooth muscle cells (VSMCs), and its expression is significantly downregulated in dedifferentiated VSMCs and atherosclerotic arteries. miR-145 plays a critical role in modulating VSMC phenotype. Because phenotypic modulation of VSMCs is an initial cellular event in the development of atherosclerosis, miRNAs, and miR-145 in particular, may represent new therapeutic targets for atherosclerosis.
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