Journal
G3-GENES GENOMES GENETICS
Volume 3, Issue 2, Pages 217-223Publisher
GENETICS SOC AM
DOI: 10.1534/g3.112.005132
Keywords
CNV; disease resistance; Marek's disease; chicken
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Funding
- U.S. Department of Agriculture (USDA)-Nation Research Initiative/National Institute of Food and Agriculture (NRI/NIFA) [2008-35204-04660]
- USDA-NRI/NIFA [2010-65205-20588]
- NIFA [2010-65205-20588, 2008-35204-04660, 583011, 581046] Funding Source: Federal RePORTER
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Breeding of genetically resistant chickens to Marek's disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry.
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