Journal
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2018.00201
Keywords
behavioral tests; rodents; open source; ImageJ; semi-automated analysis
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Funding
- Spanish Ministerio de Ciencia, Innovacion y Universidades [SAF2015-65722-R]
- Instituto de Salud Carlos III [RD12/0042/0057]
- Autonomous Region of Madrid [BRADE S2013/ICE-2958]
- Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM)
- Plan Estatal de I+D+I 2013-2016-European Regional Development Fund (FEDER) A way of making Europe,'' Spain
- Spanish Ministerio de Ciencia, Innovacion y Universidades
- Pro-CNIC Foundation
- Severo Ochoa Centre of Excellence (MINECO) [SEV-2015-0505]
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Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online.
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