Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2014.00311
Keywords
inflammation; bioenergetics; DAMP; mitochondria; Alzheimer's disease
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Funding
- University of Kansas Alzheimer's Disease Center [P30AG035982]
- Frank and Evangeline Thompson Alzheimer's Treatment Program Fund
- Hugh and Betty Libby Foundation
- Gene and Marge Sweeney Chair, KU ADC Pilot program, Landon Center for Aging, Frontiers the Heartland Institute for Clinical and Translational Research
- KUMC Biomedical Research Training Program
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Inflammation is observed in Alzheimers disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no foreign agent has been implicated. This suggests that internally produced damage-associated molecular pattern (DAMPs) molecules may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed.
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