Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2014.00251
Keywords
Alzheimer's disease; cerebral amyloid angiopathy; perivascular drainage; basement membrane; beta-amyloid
Categories
Funding
- Age UK
- BBSRC
- BBSRC [BB/K015540/1] Funding Source: UKRI
- Alzheimers Research UK [ARUK-SRF2012-2] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/K015540/1] Funding Source: researchfish
Ask authors/readers for more resources
Cerebral amyloid angiopathy (CAA), the accumulation of beta-amyloid (A beta) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) brains and is thought to be due to a failure of the aging brain to clear A beta. Perivascular drainage of A beta along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which A beta is removed from the brain. CVBMs are specialized sheets of extracellular matrix that provide structural and functional support for cerebral blood vessels. Changes in CVBM composition and structure are observed in the aged and AD brain and may contribute to the development and progression of CAA. This review summarizes the properties of the CVBM, its role in mediating clearance of interstitial fluids and solutes from the brain, and evidence supporting a role for CVBM in the etiology of CAA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available