Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2013.00094
Keywords
spatial navigation; aging; allocentric navigation; egocentric navigation; spatial learning; gender; Alzheimer's disease; hippocampus
Categories
Funding
- Grant Agency of Charles University in Prague [546113, 624012]
- European Regional Development Fund - Project FNUSA-ICRC [CZ.1.05/1.1.00/02.0123]
- European Social Fund
- State Budget of the Czech Republic
- European Social Fund within the project Young Talent Incubator II [CZ.1.07/2.3.00/20.0117]
- Ministry of Health, Czech Republic - conceptual development of research organization
- University Hospital Motol, Prague, Czech Republic [00064203]
- Institutional Support of Laboratory Research Grant [699002]
- [AV0Z50110509]
- [RVO:67985823]
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Older age is associated with changes in the brain, including the medial temporal lobe, which may result in mild spatial navigation deficits, especially in allocentric navigation. The aim of the study was to characterize the profile of real-space allocentric (world-centered, hippocampus-dependent) and egocenric (body-centered, parietal lobe dependent) navigation and learning in young vs. older adults, and to assess a possible influence of gender. We recruited healthy participants without cognitice deficits on standard neuropsychological testing, white mater lesions or pronounced hippocampal atrophy: 24 young participants (18-26 yars old) and 44 older participants stratified as participants 60-70 years old (n = 24) and participants 71-84 years old (n = 20). All underwent spatial navigation testing in the real-space human analog of the Morris Water Maze, which has the advantage of assessing separately allocentric and egocentric navigation and learning. Of the eight consecutive trials, trials 2-8 were used to reduce bias by a rebound effect (more dramatic changes in performance between trials (p < 0.001), but not those 60-70 years old, showed deficits in allocentric navigation compared to the young participants. There were no differences in egocentric navigation. All theree groups showed spatial learning effect (p' s <= 0.01). There were no gender differences in spatial navigation and learning. Linear regression limited to older participants showed linear (beta = 0.30, p = 0.045) and quadratic (beta = 0.30, p = 0.046) effect of age on allocentric navigation. There was no effect of age on egocentric navigation. These results demonstrate that navigation deficits in older age may be limited to allocentric navigation, whereas egocentric navigation deficits in older age may be limited to allocentric navigation, pattern of spacial navigation impairment may help differentiate normal aging from prodromal Alzheimer's disease.
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