Journal
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
Volume 14, Issue 2, Pages 221-233Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737167.2014.894462
Keywords
EQ-5D; smallest worthwhile effect; minimum relevant difference; review; minimum clinically important difference; Euro QoL
Funding
- Chief Scientist Office of the Scottish Government Health and Social Care Directorates
- Chief Scientist Office [HERU1] Funding Source: researchfish
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The European Quality of Life-5 Dimensions Questionnaire (EQ-5D) is the most common instrument to value health outcomes under the patient's perspective. Several studies have investigated whether observed changes are meaningful to patients, using a variety of approaches to estimate the minimum clinically important difference (MCID). This study provides an overview of the state of art of the estimation of the MCID for the three-level EQ-5D index based on the UK scoring algorithm, critically assessing the available evidence. The interest in estimation of MCID for the EQ-5D has been increasing in recent years. However, some additional standardization in the estimation procedures may be of value, in order to enhance the ability to make comparisons across measures and disease areas. Further methodological research might also contribute to reducing gaps between theory and practice.
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