Journal
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
Volume 12, Issue 4, Pages 525-538Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/ERP.12.40
Keywords
cost-effectiveness; Delphi survey; healthcare costs; Markov model; multiple sclerosis; pharmacoeconomic analysis; Sativex (R); spasticity
Funding
- Almirall, Barcelona, Spain
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Background: Multiple sclerosis (MS) is a chronic, progressive disease that carries a high socioeconomic burden. Spasticity (rigidity and spasms) is common in MS and a key contributor to MS-related disability. Objectives: This study evaluated the cost effectiveness of Sativex (R), a 9-8-tetrahydrocannabinol/cannabidiol-based oromucosal spray that acts as an endocannabinoid system modulator. Sativex was recently approved for the management of resistant MS spasticity as add-on medication. Methods: A Markov model-based analysis was performed over a 5-year horizon from a German and Spanish healthcare payer perspective. The incremental cost of Sativex was low compared with current spasticity treatments, and provided a quality-adjusted life-year gain over the current standard of care. Results: The base-case incremental cost effectiveness ratio for Sativex was estimated at (sic)11,214/quality-adjusted life-year in Germany, while the drug was the dominant option in Spain, providing savings of (sic)3496/patient over a 5-year period (year of costing: 2010). This was seen because the lower severity of spasticity in patients who had improved led to reduced resource consumption (e.g., physiotherapy and medications). Conclusion: Despite having a relatively high acquisition cost, Sativex was shown to be a cost effective treatment option for patients with MS-related spasticity.
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