Journal
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
Volume 21, Issue 10, Pages 1242-1248Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/2047487313494028
Keywords
Cardiovascular diseases; inflammation; obesity; risk factors
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Funding
- Finnish Foundation for Cardiovascular Research
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Background Highly prevalent metabolic syndrome (MS) is a major public health problem worldwide. Insulin resistance and central obesity are postulated to be the key components of this metabolic syndrome, and inflammation also plays a role in cardiovascular events. In previous years, many definitions of metabolic syndrome have emerged. Design and methods The value of MS as a predictor of cardiovascular events in median 18-year follow-up was studied in a prospective study cohort that included 1004 Finnish males and females. Cardiovascular disease included major coronary heart disease and stroke (excluding subarachnoid hemorrhage)whichever of these happened first. Results Subjects with metabolic syndrome had a 2.01-fold (95% CI 1.46-2.77) higher probability for any cardiovascular event compared with subjects with no MS. hsCRP seemed to increase the risk prediction, whereas adiponectin was not helpful. Those having five components of MS had hazard ratios of 7.89 (2.26-27.60) for any cardiovascular event in the follow-up when compared with those having no components and adjusting by traditional risk factors (p<0.01). Conclusions MS is an important predictor of cardiovascular events and is most harmful in combination with high plasma hsCRP. The clustering of components is especially harmful.
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