Journal
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
Volume 20, Issue 2, Pages 157-167Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ehjci/jey135
Keywords
hypertrophic cardiomyopathy; fibrosis progression; microvascular dysfunction; clinical outcomes; myocardial energetics; late gadolinium enhancement
Funding
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- British Heart Foundation
- NIHR Oxford Biomedical Research Centre
- British Heart Foundation Clinical Research Training Fellowship [098436/Z/12/Z]
- NIHR academic clinical fellowship
- Sir Henry Dale Fellowship - Wellcome Trust
- Sir Henry Dale Fellowship - Royal Society [098436/Z/12/B]
- NIHR Barts Biomedical Research Centre
- Wellcome Trust [WT098519MA]
- British Heart Foundation [FS/18/3/33292]
- Cancer Research UK
- Oxford British Heart Foundation Center of Research Excellence
- U.S. National Institute of Heath (NIH) [U01HL117006-01A1]
- Wellcome Trust [098436/Z/12/Z] Funding Source: Wellcome Trust
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Aims Myocardial fibrosis as detected by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is a powerful prognostic marker in hypertrophic cardiomyopathy (HCM) and may be progressive. The precise mechanisms underlying fibrosis progression are unclear. We sought to assess the extent of LGE progression in HCM and explore potential causal mechanisms and clinical implications. Methods and results Seventy-two HCM patients had two CMR (CMR1-CMR2) at an interval of 5.7 +/- 2.8years with annual clinical follow-up for 6.3 +/- 3.6 years from CMR1. A combined endpoint of heart failure progression, cardiac hospitalization, and new onset ventricular tachycardia was assessed. Cine and LGE imaging were performed to assess left ventricular (LV) mass, function, and fibrosis on serial CMR. Stress perfusion imaging and cardiac energetics were undertaken in 38 patients on baseline CMR (CMR1). LGE mass increased from median 4.98g [interquartile range (IQR) 0.97-13.48 g] to 6.30g (IQR 1.38-17.51 g) from CMR1 to CMR2. Substantial LGE progression (Delta LGE >= 4.75 g) occurred in 26% of patients. LGE increment was significantly higher in those with impaired myocardial perfusion reserve (
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