Journal
CURRENT STEM CELL RESEARCH & THERAPY
Volume 9, Issue 3, Pages 205-214Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X09666140213155800
Keywords
Cell differentiation; craniofacial reconstruction; embryonic stem cells; induced pluripotent stem cells; regenerative medicine; somatic cells
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Funding
- National Natural Science Foundation of China [31170929]
- Doctoral Fund of Ministry of Education of China [20130181110012]
- Funding of State Key Laboratory of Oral Diseases [SKLOD201402]
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The craniofacial region contains many specified tissues, including bone, cartilage, muscle, blood vessels, fat, skin and neurons. A defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly sought. The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response for craniofacial wound-healing. The recently acquired ability to reprogram human adult somatic cells to induced pluripotent stem cells (iPSCs) in culture may provide a powerful tool for in vitro disease modeling and an unlimited source for cell replacement therapy. This review focuses on the generation, biological characterization and discussion of the potential application of iPSCs for craniofacial tissue-engineering applications.
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