Journal
CURRENT STEM CELL RESEARCH & THERAPY
Volume 8, Issue 3, Pages 210-216Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X11308030005
Keywords
Bone repair; scaffolds; stem cells; tissue engineering
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The management of extensive bone defects in the setting of fracture repair, non-union and revision arthroplasty are challenging problems. The supply of harvestable autologous bone graft is limited, with an associated morbidity, and therefore a need exists for a better solution in large defects. The use of stem cells is an evolving field of research, with different potential applications, ranging from simple injection of cells to tissue engineering using osteogenic cells seeded onto a scaffold. This systematic review aims to collate the published preclinical and clinical studies investigating the potential use of stem cells for bone repair.
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