Journal
CURRENT OPINION IN VIROLOGY
Volume 7, Issue -, Pages 11-18Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2014.03.005
Keywords
-
Categories
Funding
- University of Saskatchewan
- National Science and Engineering Research Foundation [RGPIN-342475]
- Saskatchewan Health Research Foundation [RAPID 1927]
- McGill University
Ask authors/readers for more resources
MicroRNAs (miRNAs) are small non-coding RNAs that function as part of RNA-induced silencing complexes that repress the expression of target genes. Over the past few years, miRNAs have been found to mediate complex regulation of a wide variety of mammalian viral infections, including Hepatitis C virus (HCV) infection. Here, we focus on a highly abundant, liver-specific miRNA, miR-122. In a unique and unusual interaction, miR-122 binds to two sites in the 5' untranslated region (UTR) of the HCV genome and promotes viral RNA accumulation. We will discuss what has been learned about this important interaction to date, provide insights into how miR-122 is able to modulate HCV RNA accumulation, and how miR-122 might be exploited for antiviral intervention.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available