Journal
CURRENT OPINION IN VIROLOGY
Volume 9, Issue -, Pages 74-83Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2014.09.011
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Funding
- NIGMS NIH HHS [R01 GM087405] Funding Source: Medline
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RNA synthesis and replication of the members of the Flay! virus genus (including dengue, West Nile and Japanese encephalitis viruses) is regulated by a wide variety of mechanisms and actors. These include the sequestration of the RNA-dependent RNA polymerase (RdRp) for functions other than RNA synthesis, regulatory interactions with other viral and host proteins within the replication complex (RC), and regulatory elements within the RNA genome itself. In this review, we discuss our current knowledge of the multiple levels at which Flavivirus RNA synthesis is controlled. We aim to bring together two active research fields: the structural and functional biology of individual proteins of the RC and the impressive wealth of knowledge acquired regarding the viral genomic RNA.
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