Journal
CURRENT OPINION IN VIROLOGY
Volume 3, Issue 3, Pages 227-232Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2013.04.005
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Funding
- Public Health Service [R01 CA65883, R01 AI18757, RO1 AI062989, K25-AI079404]
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Epstein-Barr virus (EBV) maintains a lifelong infection. According to the germinal center model (GCM), latently infected B cells transit the germinal center (GC) to become resting memory cells. Here, the virus resides quiescently occasionally reactivating to infect new B cells, completing the cycle of infection. The GCM remains the only model that explains EBV biology and the pathogenesis of lymphoma. Recent work suggests modifications to the model notably that the virus contributes only modestly to the GC process and predictions from mathematical models that quiescence within memory B cells shapes the overall structure of viral infection but is not essential for persistence. Rather, it is the cycle of infection which allows viral persistence at the very low levels observed.
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