Journal
CURRENT OPINION IN VIROLOGY
Volume 1, Issue 6, Pages 624-634Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2011.10.012
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Funding
- National Institutes of Health [U54 AI057157-08, RO1 RO1AI085524]
- UNC-CH Medical Science Training Program [T32GM008719]
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Most new emerging viruses are derived from strains circulating in zoonotic reservoirs. Coronaviruses, which had an established potential for cross-species transmission within domesticated animals, suddenly became relevant with the unexpected emergence of the highly pathogenic human SARS-CoV strain from zoonotic reservoirs in 2002. SARS-CoV infected approximately, 8000 people worldwide before public health measures halted the epidemic. Supported by robust time-ordered sequence variation, structural biology, well-characterized patient pools, and biological data, the emergence of SARS-CoV represents one of the best-studied natural models of viral disease emergence from zoonotic sources. This review article summarizes previous and more recent advances into the molecular and structural characteristics, with particular emphasis on host-receptor interactions, that drove this remarkable virus disease outbreak in human populations.
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