Journal
CURRENT OPINION IN VIROLOGY
Volume 1, Issue 6, Pages 476-486Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2011.11.001
Keywords
-
Categories
Funding
- NIAID NIH HHS [U01 AI082994, R01 AI028900, U54 AI057158, U54 AI057158-09, R01 AI047226, U01 AI082994-03, R01 AI028900-20, R01 AI047226-04] Funding Source: Medline
Ask authors/readers for more resources
The type I and III interferon (IFN) families consist of cytokines rapidly induced during viral infection that confer antiviral protection on target cells and are critical components of innate immune responses and the transition to effective adaptive immunity. The regulation of their expression involves an intricate and stringently regulated signaling cascade, initiated by recognition most often of viral nucleic acid in cytoplasmic and endosomal compartments and involving a series of protein conformational rearrangements and interactions regulated by helicase action, ubiquitin modification, and protein aggregation, culminating in kinase activation and phosphorylation of critical transcription factors and their regulators. The many IFN subtypes induced by viruses confer amplification, diversification, and cell-type specificity to the host response to infection, providing fertile ground for development of antiviral therapeutics and vaccines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available