Journal
CURRENT OPINION IN VIROLOGY
Volume 1, Issue 5, Pages 419-422Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2011.09.001
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Funding
- MICINN [BFU2008-0216/BMC]
- Fundacion R. Areces [BFU2008-0216/BMC]
- Instituto de Salud Carlos III
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Lethal mutagenesis aims at extinguishing viruses by increased mutagenesis prompted by virus-specific mutagenic agents, mainly nucleoside analogues. It is derived from the error threshold relationship of quasispecies theory, and it is slowly finding its way towards a clinical application. We summarize the current situation of research in this field of antiviral therapy.
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