Journal
CURRENT OPINION IN VIROLOGY
Volume 1, Issue 3, Pages 160-166Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2011.05.006
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Funding
- NIH [AI09484, AI45927, 5 T32 HL007195-34, 2 T32 NS041219-11]
- [AI70967]
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Viruses must modulate or suppress their host's immune system in order to persist. In this review, we discuss the means in which the lymphocytic choriomenengitis virus targets and infects an essential component of the immune system, the dendritic cell, essential to bridging the innate and adaptive immune response. Infection of these cells results in pleiotropic effects that serve to deregulate the host immune response.
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