Journal
CURRENT HEMATOLOGIC MALIGNANCY REPORTS
Volume 7, Issue 2, Pages 133-143Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11899-012-0122-5
Keywords
ALL; Acute lymphoblastic leukemia; SNP array; Next generation sequencing
Categories
Funding
- European LeukemiaNet
- AIL
- AIRC
- Fondazione Del Monte di Bologna e Ravenna
- FIRB
- Ateneo RFO
- Project of integreted program (PIO)
- Programma di Ricerca Regione-Universita
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During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T- acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.
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