Journal
CURRENT HEMATOLOGIC MALIGNANCY REPORTS
Volume 5, Issue 3, Pages 140-147Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11899-010-0053-y
Keywords
Hodgkin lymphoma; Anti-CD30 antibodies; Brentuximab vedotin; SGN-35
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Funding
- Seattle Genetics
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Treatment of refractory or relapsed classical Hodgkin lymphoma (HL) remains challenging, but targeted immunotherapy has recently emerged as a potential treatment option for these patients. Although first-generation monoclonal anti-CD30 antibodies proved disappointing, current efforts to modify anti-CD30 antibodies to improve binding of effector cells and enhance activity appears more promising, as does the development of novel antibody-drug conjugates (ADCs). ADCs offer the potential to deliver potent therapies with minimal toxicity. One highly active ADC, brentuximab vedotin (SGN-35), combines an anti-CD30 monoclonal antibody and the antitubulin agent monomethyl auristatin E. Initial phase 1 studies of brentuximab vedotin showed a 52% overall response rate in relapsed HL, with minimal toxicity. This article highlights the development of anti-CD30 antibodies and ADCs for relapsed or refractory classical HL.
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