Journal
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
Volume 3, Issue 4, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a010306
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Funding
- NCCIH NIH HHS [R01 AT002058] Funding Source: Medline
- NCRR NIH HHS [P41 RR000954] Funding Source: Medline
- NIAID NIH HHS [R37 AI029549, R37 AI048689, R01 AI029549, R01 AI048689, U54 AI057160, R01 AI099099, R01 AI049950] Funding Source: Medline
- NIDDK NIH HHS [P50 DK064540, R01 DK051406, RC1 DK086378] Funding Source: Medline
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Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a multicellular behavior that facilitates and/or prolongs survival in diverse environmental niches. Biofilms form on biotic and abiotic surfaces both in the environment and in the healthcare setting. In hospital wards, the formation of biofilms on vents and medical equipment enables pathogens to persist as reservoirs that can readily spread to patients. Inside the host, biofilms allow pathogens to subvert innate immune defenses and are thus associated with long-term persistence. Here we provide a general review of the steps leading to biofilm formation on surfaces and within eukaryotic cells, highlighting several medically important pathogens, and discuss recent advances on novel strategies aimed at biofilm prevention and/or dissolution.
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