Journal
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
Volume 3, Issue 10, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a014415
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Funding
- Pediatric Brain Tumor Foundation
- American Cancer Society [PF-13-295-01-TBG]
- National Institutes of Health [CA133091, CA102321, CA128583, CA148699, CA159859, CA163155, CA081403]
- Cancer League Foundation
- Alex's Lemonade Stand Foundation
- Katie Dougherty Foundation
- St Baldrick's Foundation
- Samuel G. Waxman Foundation
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Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in similar to 25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
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