Journal
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
Volume 2, Issue 5, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a006940
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Funding
- Medical Research Council [G1000196, G1001081, G0401570] Funding Source: Medline
- NIAID NIH HHS [R37 AI064003] Funding Source: Medline
- NIMH NIH HHS [P01 MH100942] Funding Source: Medline
- MRC [G1001081, G0401570, G1000196] Funding Source: UKRI
- Medical Research Council [G1000196, G1001081, G0401570] Funding Source: researchfish
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Retroviruses have long been a fertile model for discovering host-pathogen interactions and their associated biological principles and processes. These advances have not only informed fundamental concepts of viral replication and pathogenesis but have also provided novel insights into host cell biology. This is illustrated by the recent descriptions of host-encoded restriction factors that can serve as effective inhibitors of retroviral replication. Here, we review our understanding of the three restriction factors that have been widely shown to be potent inhibitors of HIV-1: namely, APOBEC3G, TRIM5 alpha, and tetherin. In each case, we discuss how these unrelated proteins were identified, the mechanisms by which they inhibit replication, the means used by HIV-1 to evade their action, and their potential contributions to viral pathogenesis as well as inter-and intraspecies transmission.
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