Journal
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
Volume 2, Issue 9, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a006452
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- National Institutes of Health (NIH) [R01s HL43174, HL86465]
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VEGF-A signaling is required for almost every aspect of vascular development, and it is a major regulator of vessel morphogenesis and patterning. VEGF-A perturbations are associated with severe vascular defects and lethality, and the pathway is coopted in pathological scenarios, including tumor angiogenesis. This review focuses on the roles of VEGF-A signaling during vessel development and patterning. I review the impact of VEGF-A signaling on endothelial cells in developing vessels, with emphasis on the importance of spatial regulation of several pathway components. I also discuss VEGF-A signaling patterns at the level of the vessel, with a focus on how polarity is set up and maintained in several vessel axes. The role of VEGF-A in patterning vessels relative to tissues and organs is also reviewed, with emphasis on neurovascular patterning and patterning at the embryonic midline.
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