Journal
CHEMPLUSCHEM
Volume 79, Issue 1, Pages 171-180Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201300242
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Funding
- Region Champagne-Ardenne
- Europe (FEDER)
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The elaboration, characterisation and efficiency of potential two-photon-excited photodynamic therapy (PDT) treatment of new poly(D,L-lactide-co-glycolide) nanoparticles loaded with ruthenium(II) complexs are presented. The materials are based on the encapsulation of Ru-II complexes through an all-biocompatible process. The size of the nanoparticles is around 100 nm. The internal concentration is several orders of magnitude higher than the overall concentration, which leads to a more efficient and targeted effect. The therapeutic potential for PDT of these nanoparticles has been studied in vitro on C6 glioma cells.
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