Journal
CHEMPLUSCHEM
Volume 80, Issue 1, Pages 209-216Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201402200
Keywords
aldol reaction; copper; diastereoselectivity; helical structures; homogeneous catalysis
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Funding
- DST-SERB [SR/S1/IC-23/2011]
- CSIR, New Delhi [CSC0123]
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Polydentate ligands 1 and 2, which incorporate a terminal pyridyl moiety and an oxygen-rich oxalate dihydrizide/malonic dihydrizide spacer moiety, as well as their binuclear metal complexes [Cu(2)1(2)] and [Cu(2)2(2)], which adopt a 1:1 metal/ligand ratio, were synthesized and characterized. Both complexes were screened for their catalytic activity in the nitroaldol reaction, in which [Cu(2)1(2)] worked efficiently as catalyst for both substituted benzaldehyde and pyridinecarboxaldehyde, where-as [Cu(2)2(2)] is highly substrate specific and showed activity towards nitro-substituted aldehydes and pyridinecarboxaldehyde. Furthermore, as helicates are intrinsically chiral, the stereochemical architecture in the binuclear double-stranded Cu-2 helicates as catalyst favored the diastereoselective syn product with nitroethane and nitropropane and their respective diastereoselectivities were determined by using H-1 NMR spectroscopy.
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