Journal
CHEMPLUSCHEM
Volume 78, Issue 1, Pages 20-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201200256
Keywords
bioinorganic chemistry; coordination chemistry; nucleic acids; nucleosides; transition metals
Categories
Funding
- DFG [SFB 858]
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Metal-mediated base pairs represent an elegant way for the site-specific functionalisation of nucleic acids. In this type of base pair, the hydrogen bonds between complementary nucleobases are replaced formally by coordinative bonds to one or more transition-metal ions. This Review presents an overview of metal-mediated base pairs reported so far. It gives an insight into the characterisation of metal-mediated base pairs and into the structures of the resulting metal-modified nucleic acids. In addition, a summary of applications exploiting the formation of metal-mediated base pairs is presented. The applications include, for example, metal-ion sensors of various types, a protein sensor, and DNA-based molecular machines. Initial reports on the potential use of metal-mediated base pairs in the context of charge transfer through nucleic acid double helices are summarised as well.
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