Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 293, Issue -, Pages 96-106Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2015.07.024
Keywords
memory loss; synaptic loss; growth factor; insulin; incretin; LTP
Categories
Funding
- Alzheimer Society UK
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Type 2 diabetes is a risk factor for Alzheimer's disease (AD). Previously, we have shown that the diabetes drug liraglutide is protective in middle aged and in old APP/PS1 mice. Here, we show that liraglutide has prophylactic properties. When injecting liraglutide once-daily ip. in two months old mice for 8 months, the main hallmarks of AD were much reduced. Memory formation in object recognition and Morris water maze were normalised and synapse loss and the loss of synaptic plasticity was prevented. In addition, amyloid plaque load, including dense core congophilic plaques, was much reduced. Chronic inflammation (activated microglia) was also reduced in the cortex, and neurogenesis was enhanced in the dentate gyrus. The results demonstrate that liraglutide may protect from progressive neurodegeneration that develops in AD. The drug is currently in clinical trials in patients with AD. (C) 2015 Elsevier B.V. All rights reserved.
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