Journal
CELL REPORTS
Volume 24, Issue 12, Pages 3194-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.08.059
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Funding
- Biotechnology and Biological Sciences Research Council [BB/N00230X/1]
- Wellcome Trust [090309/Z/09/Z, 090532/Z/09/Z]
- Gatsby Charitable Foundation [GAT3237]
- Oxford Martin School
- NIH grant [P40OD018537]
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P40OD018537] Funding Source: NIH RePORTER
- BBSRC [BB/N00230X/1] Funding Source: UKRI
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A balanced diet of macronutrients is critical for animal health. A lack of specific elements can have profound effects on behavior, reproduction, and life-span. Here, we used Drosophila to understand how the brain responds to carbohydrate deprivation. We found that serine protease homologs (SPHs) are enriched among genes that are transcriptionally regulated in flies deprived of carbohydrates. Stimulation of neurons expressing one of these SPHs, Scarface (Scaf), or overexpression of scaf positively regulates feeding on nutritious sugars, whereas inhibition of these neurons or knockdown of scaf reduces feeding. This modulation of food intake occurs only in sated flies while hunger-induced feeding is unaffected. Furthermore, scaf expression correlates with the presence of sugar in the food. As Scaf and Scaf neurons promote feeding independent of the hunger state, and the levels of scaf are positively regulated by the presence of sugar, we conclude that scaf mediates the hedonic control of feeding.
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