Journal
CELL REPORTS
Volume 24, Issue 4, Pages 791-800Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.06.093
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Funding
- Human Frontier Science Program fellowship [LT000506/2013-L]
- Netherlands Organization for Scientific Research (NWO) [022.003.003]
- European Research Council (ERC) [617050]
- ERC [336291]
- Marie Curie fellowship [661401]
- NWO [NWO-ALW-VICI 865.10.010, 184.032.201]
- VIDI grant [723.012.102]
- [NWO-ALW-VICI 865.14.004]
- [NWO-ALW-VIDI 864.12.008]
- Marie Curie Actions (MSCA) [661401] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [336291] Funding Source: European Research Council (ERC)
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Neuron morphology and function are highly dependent on proper organization of the cytoskeleton. In neurons, the centrosome is inactivated early in development, and acentrosomal microtubules are generated by mechanisms that are poorly understood. Here, we show that neuronal migration, development, and polarization depend on the multi-subunit protein HAUS/augmin complex, previously described to be required for mitotic spindle assembly in dividing cells. The HAUS complex is essential for neuronal microtubule organization by ensuring uniform microtubule polarity in axons and regulation of microtubule density in dendrites. Using live-cell imaging and high-resolution microscopy, we found that distinct HAUS clusters are distributed throughout neurons and colocalize with gamma-TuRC, suggesting local microtubule nucleation events. We propose that the HAUS complex locally regulates microtubule nucleation events to control proper neuronal development.
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