Journal
CELL REPORTS
Volume 3, Issue 6, Pages 1815-1823Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2013.05.014
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Funding
- Agence Nationale pour la Recherche [ANR-10-BLAN-141-01, ANR-11-BLAN-069467]
- Global Research Laboratory Program [2009-00424]
- Korean Ministry of Education, Science and Technology
- Region Ile de France
- NIH [1 DP1 OD 003699]
- NIMH [5P50MH094271]
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Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant circuits and in the primary visual cortex reopens binocular plasticity to restore vision in amblyopic mice. The potential to regulate adult cortical plasticity through the choroid plexus underscores the importance of this structure in brain physiology and offers therapeutic approaches to recovery from a broad range of neurodevelopmental disorders.
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