Journal
CELL REPORTS
Volume 5, Issue 3, Pages 727-737Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2013.09.030
Keywords
-
Categories
Funding
- Spanish Ministry of Science and Innovation [SAF2010-21143, BFU2008-01042, CSD2007-00023, CDS2007-00017]
- Generalitat Valenciana [Prometeo 2008/049, PROMETEOII/2013/002]
Ask authors/readers for more resources
Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A. Here, we show that eEF1A binds to Snail transcription factors when bound to their main target, the E-cadherin promoter, facilitating their export to the cytoplasm in association with the aa-tRNA-Exportin5 complex. Snail binds to eEF1A through the SNAG domain, a protein nuclear export signal present in several transcription factor families, and this binding is regulated by phosphorylation. Thus, we describe a nuclear role for eEF1A and provide a mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available