Journal
CELL REPORTS
Volume 3, Issue 5, Pages 1457-1464Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2013.04.019
Keywords
-
Categories
Funding
- Center for Cancer Research Intramural Program, National Cancer Institute (NCI), National Institutes of Health, a part of the U.S. Department of Health and Human Services
- NCI [HHSN261200800001E, NIH HL34788]
- NIGMS [U54 GM069338]
Ask authors/readers for more resources
GPR116 is an orphan seven-pass transmembrane receptor whose function has been unclear. Global disruption of the Gpr116 gene in mice revealed an unexpected, critical role for this receptor in lung surfactant homeostasis, resulting in progressive accumulation of surfactant lipids and proteins in the alveolar space, labored breathing, and a reduced lifespan. GPR116 expression analysis, bone marrow transplantation studies, and characterization of conditional knockout mice revealed that GPR116 expression in ATII cells is required for maintaining normal surfactant levels. Aberrant packaging of surfactant proteins with lipids in the Gpr116 mutant mice resulted in compromised surfactant structure, function, uptake, and processing. Thus, GPR116 plays an indispensable role in lung surfactant homeostasis with important ramifications for the understanding and treatment of lung surfactant disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available