Journal
CELL REPORTS
Volume 5, Issue 3, Pages 769-780Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2013.09.032
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Funding
- Fondation pour la Recherche Medicale
- French Agence Nationale de la Recherche
- Bernstein Focus Learning via BMBF
- Max-Planck-Gesellschaft
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One of the challenges facing memory research is to combine network- and cellular-level descriptions of memory encoding. In this context, Drosophila offers the opportunity to decipher, down to single-cell resolution, memory-relevant circuits in connection with the mushroom bodies (MBs), prominent structures for olfactory learning and memory. Although the MB-afferent circuits involved in appetitive learning were recently described, the circuits underlying appetitive memory retrieval remain unknown. We identified two pairs of cholinergic neurons efferent from the MB a vertical lobes, named MB-V3, that are necessary for the retrieval of appetitive long-term memory (LTM). Furthermore, LTM retrieval was correlated to an enhanced response to the rewarded odor in these neurons. Strikingly, though, silencing the MB-V3 neurons did not affect short-term memory (STM) retrieval. This finding supports a scheme of parallel appetitive STM and LTM processing.
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