Journal
CELL AND BIOSCIENCE
Volume 3, Issue -, Pages -Publisher
BMC
DOI: 10.1186/2045-3701-3-4
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Funding
- NIH
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TGF-beta 1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-beta 1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-beta 1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones.
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