Journal
CELL AND BIOSCIENCE
Volume 3, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/2045-3701-3-7
Keywords
Filamin-A; ABP-280; Actin filament; Cytoskeleton; DNA repair; Metastasis
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Funding
- NCI NIH HHS [R01 CA156706] Funding Source: Medline
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Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally identified as a non-muscle actin binding protein, which organizes filamentous actin into orthogonal networks and stress fibers. Filamin-A also anchors various transmembrane proteins to the actin cytoskeleton and provides a scaffold for a wide range of cytoplasmic and nuclear signaling proteins. Intriguingly, several studies have revealed that filamin-A associates with multiple non-cytoskeletal proteins of diverse function and is involved in several unrelated pathways. Mutations and aberrant expression of filamin-A have been reported in human genetic diseases and several types of cancer. In this review, we discuss the implications of filamin-A in cancer progression, including metastasis and DNA damage response.
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