Journal
CELL AND BIOSCIENCE
Volume 2, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/2045-3701-2-9
Keywords
TGF-beta receptor; phosphorylation; ubiquitination; degradation
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Funding
- National Natural Science Foundation of China [30921004, 91019003, 30930050]
- 973 Program [2011CBA01104, 2011CB943803, 2010CB833706]
- Tsinghua University Initiative Scientific Research Program [2010THZ0]
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TGF-beta signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-beta signaling is tightly regulated at different levels along the pathway, and modulation of TGF-beta receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-beta receptor activity.
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