Journal
CELL AND BIOSCIENCE
Volume 1, Issue -, Pages -Publisher
BMC
DOI: 10.1186/2045-3701-1-20
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Funding
- Canadian Institutes of Health Research
- Canadian Cystic Fibrosis Foundation
- Foundation Fighting Blindness-Canada
- CCFF Zellers Senior Scientist Award
- Premier's Research Excellence Award of Ontario, Canada
- CCFF doctoral award
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Dendritic cells (DCs) play a key role in initiating immune responses and maintaining immune tolerance. In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which are dependent on IL-10, TGF-beta, retinoic acid, indoleamine-2,3,-dioxygenase along with vitamin D. Several of these mechanisms are employed by DCs in induction of regulatory T cells which are comprised of Tr1 regulatory T cells, natural and inducible foxp3(+) regulatory T cells, Th3 regulatory T cells and double negative regulatory T cells. It appears that certain DC subsets are highly specialized in inducing regulatory T cell differentiation and in some tissues the local microenvironment plays a role in driving DCs towards a tolerogenic response. In this review we discuss the recent advances in our understanding of the mechanisms underlying DC driven regulatory T cell induction.
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