Journal
GENES
Volume 6, Issue 4, Pages 1113-1124Publisher
MDPI
DOI: 10.3390/genes6041113
Keywords
bacterial diversity; trade-offs; nutrient uptake; outer membranes; antibiotic susceptibility
Categories
Funding
- Australian Research Council
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Variations in porin proteins are common in Gram-negative pathogens. Altered or absent porins reduce access of polar antibiotics across the outer membrane and can thus contribute to antibiotic resistance. Reduced permeability has a cost however, in lowering access to nutrients. This trade-off between permeability and nutritional competence is the source of considerable natural variation in porin gate-keeping. Mutational changes in this trade-off are frequently selected, so susceptibility to detergents and antibiotics is polymorphic in environmental isolates as well as pathogens. Understanding the mechanism, costs and heterogeneity of antibiotic exclusion by porins will be crucial in combating Gram negative infections.
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